Alejandro San Martin

Title: Innovations in Metabolic Measurement by Inventor Alejandro San Martin

Introduction

Alejandro San Martin, an innovative inventor based in Valdivia, Chile, has made significant strides in the field of metabolic measurement technology. With a total of two patents to his name, his work emphasizes the advancement of optical tools for high-resolution detection and quantification of key metabolic substances.

Latest Patents

San Martin's latest patents include a genetically encoded probe for the quantification of lactate and methods for quantifying metabolic rates and lactate transport. This invention involves a nanosensor capable of detecting and measuring lactate in various samples such as tissues and subcellular compartments, delivering high spatial and temporal resolution. The functionalities of this nanosensor extend to determining the activity of lactate transporters and measuring cellular lactate production and consumption, which is particularly impactful in cancer research.

Additionally, he has developed a genetically encoded probe for quantifying pyruvate concentration. This optical tool, based on Forster Resonance Energy Transfer (FRET), incorporates a bacterial PdhR transcription factor, enhancing the ability to detect and quantify pyruvate in biological samples. It can also assess pyruvate transporter activity and the rates of mitochondrial pyruvate consumption in intact cells, showcasing San Martin's significant contributions to metabolic studies.

Career Highlights

Throughout his career, San Martin has collaborated with esteemed institutions, including the Centro de Estudios Científicos de Valdivia and the Carnegie Institution of Washington. His work has not only highlighted his inventiveness but also his dedication to advancing scientific understanding of metabolism.

Collaborations

During his tenure, San Martin has collaborated with several professionals in the field. Notable coworkers include Luis Felipe Barros Olmedo and Sebastian Ceballo Charpentier, who have contributed to his innovative projects and research endeavors.

Conclusion

Alejandro San Martin exemplifies the spirit of innovation in the field of metabolic measurement with his cutting-edge patents. Through his advanced optical tools and collaborative efforts, he continues to push the boundaries of research in cellular metabolism, making a valuable impact on scientific studies related to health and disease.