Alan H Sharp

Title: Alan H Sharp: Innovator in Huntington's Disease Research

Introduction

Alan H Sharp is a notable inventor based in Baltimore, MD (US). He has made significant contributions to the field of biomedical research, particularly in the study of Huntington's Disease. His work focuses on the development of assays that can aid in the screening of drug candidates for this debilitating condition.

Latest Patents

Alan H Sharp holds a patent for "Huntingtin-associated protein-related assays." This invention involves proteins that specifically bind to huntingtin, the product of the Huntington's Disease locus (HD). These proteins, known as huntingtin associated proteins, are utilized in assays for screening potential drug candidates. Notably, these proteins exhibit a stronger binding affinity to huntingtins from patients with Huntington's Disease compared to those from normal individuals. The strength of this binding correlates with the number of glutamine repeats in the huntingtin, which is associated with the timing of disease onset.

Career Highlights

Alan H Sharp is affiliated with Johns Hopkins University, where he continues to advance research in the field of neurodegenerative diseases. His work has been instrumental in understanding the molecular mechanisms underlying Huntington's Disease and developing potential therapeutic strategies.

Collaborations

Some of his notable coworkers include Christopher A Ross and Xiao-Jiang Li, who have also contributed to the research on Huntington's Disease and related fields.

Conclusion

Alan H Sharp's innovative work in the development of huntingtin-associated protein-related assays represents a significant advancement in the fight against Huntington's Disease. His contributions continue to pave the way for future research and potential treatments for this challenging condition.