The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 25, 2000
Filed:
Nov. 09, 1995
Christopher A Ross, Baltimore, MD (US);
Xiao-Jiang Li, Baltimore, MD (US);
Shi-Hua Li, Baltimore, MD (US);
Alan H Sharp, Baltimore, MD (US);
Anthony Lanahan, Baltimore, MD (US);
Paul F Worley, Baltimore, MD (US);
Solomon H Snyder, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
Proteins which specifically bind to huntingtin, the product of the Huntington's Disease locus (HD), are used in assays for screening drug candidates. These proteins, termed huntingtin associated proteins, bind to huntingtins of both normal and Huntington's Disease patients. However, the binding is stronger to the huntingtins from the patients. The strength of binding correlates with the number of glutamine repeats in the huntingtin, which itself correlates with the time of disease onset.