Adrienne Dubin

Title: The Innovative Contributions of Adrienne Dubin

Introduction

Adrienne Dubin is a prominent inventor based in San Diego, CA. She has made significant contributions to the field of pharmaceutical research, particularly in the area of neurobiology. With a total of 8 patents to her name, Dubin's work has paved the way for advancements in understanding and manipulating neuroblastoma cell lines.

Latest Patents

Among her latest patents, one notable invention provides methods to manipulate the differentiation of a neuroblastoma cell line (IMR-32). This invention allows for the predominant expression of Na1.3 in IMR-32 cells exposed to retinoic acid or Na1.7 in cells grown under non-differentiating conditions. The cells developed through this invention are instrumental for discovering new compounds that modulate the function of either Na1.3 and/or Na1.7. Another significant patent involves the human vanilloid receptor VR3 protein, where DNA encoding the human VR1 receptor has been cloned and characterized. The recombinant protein produced is capable of forming biologically active protein, which is purified from recombinant host cells. This work also establishes a method for identifying modulators of receptor activity.

Career Highlights

Adrienne Dubin is currently associated with Ortho-McNeil Pharmaceutical Corporation, where she continues to innovate and contribute to the field. Her research has been pivotal in advancing the understanding of neurobiology and its applications in pharmaceuticals.

Collaborations

Throughout her career, Dubin has collaborated with notable colleagues, including Mark G. Erlander and Arne Huvar. These collaborations have further enhanced her research and contributions to the field.

Conclusion

Adrienne Dubin's innovative work and numerous patents reflect her dedication to advancing pharmaceutical research. Her contributions have significant implications for the understanding and treatment of neuroblastoma and related conditions.