Ortho-mcneil Pharmaceutical Corp.

Adrienne Dubin

Mark G Erlander

Arne Huvar

Charles A Glass

Rene Huvar

Jayashree Pyati

Lukas K Buehler

Jessica Y Zhu

Sandra Chaplan

Sean Brown

Jose E Galindo

Edward Kaftan

The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Naexpression is either Na1.3 in IMR-32 cells exposed to retinoic acid or Na1.7 in cells grown under non-differentiating conditions. The cells of the present invention are useful for the discovery of new compounds that modulate the function of either Na1.3 and/or Na1.7.

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DNA encoding human VR1 receptor has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

Human vanilloid receptor VR3 protein

DNA encoding human 5-HT3-C has been cloned and characterized. The recombinant protein is capable of forming biologically active human 5-HT3-C protein. The cDNA has been expressed in recombinant host cells that produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

Human 5-HT3-C protein

DNA encoding human acid sensing ion channel BnaC4 has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

DNA encoding human acid-sensing ion channel BNaC4 (ASIC4)

DNA encoding human vanilloid receptor VR3

DNA encoding a human subunit 5-HT3-C of the 5-HT3 serotonin receptor

A DNA molecule encoding a novel isoform of the human T-type low voltage activated calcium channel (alpha1G-c) has been cloned and characterized. The biological and structural properties of this protein is disclosed, as is the amino acid and nucleotide sequence.

DNA encoding human alpha1G-C T-Type calcium channel

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San Diego, CA, United States of America

Adrienne Dubin