Adriana Osickova

Title: Adriana Osickova: Innovator in Immunogenic Delivery Systems

Introduction

Adriana Osickova is a prominent inventor based in Prague, Czech Republic. She has made significant contributions to the field of immunology through her innovative research and development of polypeptides. With a total of three patents to her name, her work focuses on enhancing the delivery of immunogenic molecules into cells.

Latest Patents

One of her latest patents involves mutant CyaA polypeptides and polypeptide derivatives that are suitable for delivering immunogenic molecules into a cell. This invention relates to mutant CyaA/E570Q+K860 polypeptides, which serve as proteinaceous vectors for delivering molecules of interest into cells, particularly those expressing the CD11b receptor. The polypeptides are designed to retain the binding activity of native CyaA while reducing or suppressing its pore-forming activity compared to the native CyaA toxin. The polypeptides include specific mutations that enhance their functionality while maintaining their essential properties.

Career Highlights

Adriana has worked with esteemed institutions such as the Institut Pasteur and the Institute of Microbiology of the ASCR, v.v.i. Her experience in these organizations has allowed her to collaborate with leading experts in the field and contribute to groundbreaking research.

Collaborations

Some of her notable coworkers include Peter Sebo and Claude Leclerc. Their collaborative efforts have further advanced the understanding and application of her inventions in immunology.

Conclusion

Adriana Osickova's innovative work in the development of mutant CyaA polypeptides represents a significant advancement in the field of immunogenic delivery systems. Her contributions continue to influence research and applications in immunology.