The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2011
Filed:
Mar. 23, 2009
Peter Sebo, Prague, CZ;
Claude Leclerc, Paris, FR;
Adriana Osickova, Prague, CZ;
Catherine Fayolle, Epinay sur Orge, FR;
Jiri Masin, Uvaly, CZ;
Jan Krusek, Prague, CZ;
Radim Osicka, Prague, CZ;
Marek Basler, Prague, CZ;
Peter Sebo, Prague, CZ;
Claude Leclerc, Paris, FR;
Adriana Osickova, Prague, CZ;
Catherine Fayolle, Epinay sur Orge, FR;
Jiri Masin, Uvaly, CZ;
Jan Krusek, Prague, CZ;
Radim Osicka, Prague, CZ;
Marek Basler, Prague, CZ;
Institut Pasteur, Paris, FR;
Abstract
The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host. The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin.