Company Filing History:
Years Active: 2005-2008
Title: The Innovative Contributions of Adam J Simon
Introduction
Adam J Simon is a notable inventor based in Langhorne, PA (US), recognized for his significant contributions to the field of biotechnology. He holds three patents that focus on advancements in understanding and manipulating amyloid precursor proteins, which are crucial in the study of neurodegenerative diseases.
Latest Patents
One of Simon's latest patents is titled "Transgenic mouse having an amyloid precursor protein with a modified beta secretase cleavage site." This invention provides transgenic animals with an amyloid precursor protein where the amino acids flanking the beta secretase cleavage site are modified. The invention also includes tissues and cell lines derived from these animals, along with methods for screening candidate compounds that may alter the cleavage rate of amyloid precursor protein by beta secretase.
Another significant patent is related to "Assays using amyloid precursor proteins with modified beta-secretase cleavage sites to monitor beta-secretase activity." This patent outlines methods for identifying inhibitors of beta-secretase using modified substrates that have altered cleavage sites. These modified substrates are designed to be more efficient than their wild-type counterparts, enhancing the understanding of enzymatic breakdown by beta-secretase. Additionally, the patent provides recombinant polynucleotide molecules and stable cell lines expressing these modified substrates.
Career Highlights
Adam J Simon has worked with prominent companies in the pharmaceutical industry, including Merck & Company, Inc. and Merck & Co., Inc. His experience in these organizations has contributed to his expertise in biotechnology and patent development.
Collaborations
Throughout his career, Simon has collaborated with notable colleagues such as Daria Hazuda and Elizabeth Chen Dodson. These partnerships have likely enriched his research and innovation efforts.
Conclusion
Adam J Simon's work in the field of biotechnology, particularly regarding amyloid precursor proteins, showcases his innovative spirit and dedication to advancing scientific knowledge. His patents reflect a commitment to addressing critical challenges in neurodegenerative disease research.