Company Filing History:
Years Active: 2019-2024
Title: Innovations by Aaron Jacobs in Nucleic Acid Polymerization
Introduction
Aaron Jacobs is an accomplished inventor based in Seattle, WA. He has made significant contributions to the field of nucleic acid polymerization, holding a total of four patents. His work focuses on enhancing DNA replication and sequencing technologies, which are crucial for advancements in genetic research and diagnostics.
Latest Patents
One of Jacobs' latest patents is titled "Enhancement of Nucleic Acid Polymerization by Aromatic Compounds." This invention relates to compounds, methods, and compositions that improve nucleic acid polymerization, including DNA replication through in vitro primer extension. The technology aims to generate polymers for nanopore-based single molecule sequencing of DNA templates. The patent provides a nucleic acid polymerase reaction composition with polymerization enhancement moieties, which significantly enhances DNA polymerase activity with nucleotide analogs. This results in improved lengths of primer extension products for sequencing applications.
Another notable patent is for "DPO4 Polymerase Variants with Improved Accuracy." This patent presents recombinant DPO4-type DNA polymerase variants that have amino acid substitutions, which modify the polymerase's properties for enhanced single molecule sequencing applications. These properties include improved binding and accurate incorporation of bulky nucleotide analog substrates into daughter strands. The patent also includes compositions comprising these DPO4 variants and nucleotide analogs, as well as nucleic acids encoding the polymerases with the desired phenotypes.
Career Highlights
Throughout his career, Aaron Jacobs has worked with prominent companies in the biotechnology sector, including Stratos Genomics, Inc. and Roche Sequencing Solutions, Inc. His experience in these organizations has allowed him to develop and refine his innovative approaches to nucleic acid polymerization.
Collaborations
Jacobs has collaborated with notable professionals in his field, including Mark Stamatios Kokoris and John Tabone. These collaborations have contributed to the advancement of his research and the successful development of his patented technologies.
Conclusion
Aaron Jacobs is a pioneering inventor whose work in nucleic acid polymerization has the potential to revolutionize genetic research and sequencing technologies. His patents reflect a commitment to enhancing the accuracy and efficiency of DNA replication processes.
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