The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2016
Filed:
Jul. 09, 2014
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Renee C. Gaspar, Souderton, PA (US);
Paul J. Shughrue, West Chester, PA (US);
Fubao Wang, Dresher, PA (US);
Weirong Wang, Harleysville, PA (US);
Ningyan Zhang, Ambler, PA (US);
Wei-Qin Zhao, North Wales, PA (US);
Min Xu, Ambler, PA (US);
Alexander McCampbell, Chalfont, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention relates to antibodies that bind amyloid β-derived diffusible ligands, also known as ADDLs. The antibodies of the invention are selective for ADDLs, can penetrate the brain, and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with ADDLs.