The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2013
Filed:
May. 04, 2009
Nikhil Umesh Mohe, Mumbai, IN;
Dinesh Kumar Paliwal, Mumbai, IN;
Divya Lal Saksena, Mumbai, IN;
Chandrakesan Muralidharan, Mumbai, IN;
Rakesh Shekhawat, Mumbai, IN;
Sagar Satyanarayan Zawar, Mumbai, IN;
Nikhil Umesh Mohe, Mumbai, IN;
Dinesh Kumar Paliwal, Mumbai, IN;
Divya Lal Saksena, Mumbai, IN;
Chandrakesan Muralidharan, Mumbai, IN;
Rakesh Shekhawat, Mumbai, IN;
Sagar Satyanarayan Zawar, Mumbai, IN;
USV, Ltd., Mumbai, IN;
Abstract
The present invention relates to a process for improving pegylation reaction yield of r-metHuG-CSF comprising conjugating r-metHuG-CSF to a PEG aldehyde at a free amine moiety at the N terminal end on the G-CSF in presence of a reducing agent in a pegylation buffer solution comprising a polyol having the formula CHOwhere n is from 3 to 6, or a carbohydrate, or a derivative thereof wherein the concentration of said polyol or carbohydrate or derivative thereof is in the range of 0.1% to 10% w/w.