The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2013
Filed:
Apr. 26, 2007
Osvaldo Luis Podhajcer, Buenos Aires, AR;
Eduardo Gustavo Alfredo Cafferata, Buenos Aires, AR;
Maria Veronica Lopez, La Plata, AR;
Diego Luis Viale, Buenos Aires, AR;
Osvaldo Luis Podhajcer, Buenos Aires, AR;
Eduardo Gustavo Alfredo Cafferata, Buenos Aires, AR;
Maria Veronica Lopez, La Plata, AR;
Diego Luis Viale, Buenos Aires, AR;
Consejo Nacional de Investigaciones Cientificas y Tecnicas (Conicet), Buenos Aires, AG;
Fundacion Instituto Leloir, Buenos Aires, AG;
Abstract
An isolated DNA sequence corresponding to a region of the SPARC gene human promoter from base pair −513 to base pair +35 capable of driving the expression of a heterologous gene of interest, that can be associated to any other promoter sequence, such as radiation responsive sequence, hypoxia responsive sequence and free-radical responsive sequence. The invention also provides constructs and DNA recombinant expression viral vectors, comprising the isolated sequence of the SPARC gene human promoter and at least one heterologous gene operably linked thereto, wherein the promoter sequence drives the expression of the at least one heterologous gene in tumor cells. Pharmaceutical compositions and a method for treating tumors are also provided.