The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2011
Filed:
Nov. 17, 2006
Johannes Backs, Dallas, TX (US);
Brooke Harrison, Longmont, CO (US);
Khai Huynh, Westminster, CO (US);
Keith Koch, Erie, CO (US);
Timothy A. Mckinsey, Broomfield, CO (US);
Eric Olson, Dallas, TX (US);
Nikos Pagratis, Boulder, CO (US);
Johannes Backs, Dallas, TX (US);
Brooke Harrison, Longmont, CO (US);
Khai Huynh, Westminster, CO (US);
Keith Koch, Erie, CO (US);
Timothy A. McKinsey, Broomfield, CO (US);
Eric Olson, Dallas, TX (US);
Nikos Pagratis, Boulder, CO (US);
The Board of Regents of the University of Texas Systems, Austin, TX (US);
Gilead Sciences, Inc., Foster City, CA (US);
Abstract
The present invention provides for methods of treating and cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension comprising the use of CaMKII-HDAC binding domains. The present invention discloses not only the fact that CaMKII binds to HDAC4 at a specific site, but that HDAC4 may dimerize with other HDACs. Both events can lead to export of HDACs from the nucleus to the cytoplasm, an event associated with the development of heart disease. Thus the methods of treatment and the screening methods of the present invention are novel attempts to prevent, treat or identify therapies for cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension.