The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2009
Filed:
Dec. 23, 2004
Yi-pei Chen, Yingge Township, Taipei County, TW;
Li-ling Liaw, Hsinchu, TW;
Chun-lin Wang, Hsinchu, TW;
Chung-tsai Lee, Dacun Township, Changhua County, TW;
Ing-er Hwang, Jhudong Township, Hsinchu County, TW;
Ching-ping Tseng, Hsinchu, TW;
Gwo-fang Yuan, Hsinchu, TW;
Yi-Pei Chen, Yingge Township, Taipei County, TW;
Li-Ling Liaw, Hsinchu, TW;
Chun-Lin Wang, Hsinchu, TW;
Chung-Tsai Lee, Dacun Township, Changhua County, TW;
Ing-Er Hwang, Jhudong Township, Hsinchu County, TW;
Ching-Ping Tseng, Hsinchu, TW;
Gwo-Fang Yuan, Hsinchu, TW;
Food Industry Research & Development Institute, Hsinchu, TW;
Abstract
Cholesterol inhibitor produced by, monacolin k, is a secondary metabolite of polyketides. The invention provides probes specific to monacolin k biosynthesis gene cluster. BAC clones having putative monacolin k gene cluster were screened from BAC (bacterial artificial chromosome) library, and sequencing and annotation were performed on these clones. The results show that 2 polyketide synthase (PKS) genes and 7 regulatory genes related to monacolin k synthesis were obtained. Full-length cDNAs of these genes were then obtained by RT-PCR and cloned to expression vectors for the expression of these genes.