The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2008
Filed:
May. 05, 2004
James E. Simon, Princeton, NJ (US);
Mingfu Wang, Piscataway, NJ (US);
Kodzo Gbewonyo, Somerset, NJ (US);
Mohamed M. Rafi, Highland Park, NJ (US);
Daniel Fahene Acquaye, Accra, GH;
Yaw Asianowa, Kumasi, GH;
James E. Simon, Princeton, NJ (US);
Mingfu Wang, Piscataway, NJ (US);
Kodzo Gbewonyo, Somerset, NJ (US);
Mohamed M. Rafi, Highland Park, NJ (US);
Daniel Fahene Acquaye, Accra, GH;
Yaw Asianowa, Kumasi, GH;
Rutgers, The State University, New Brunswick, NJ (US);
BioResources International Inc., Somerset, NJ (US);
Abstract
The present invention provides methods for reducing the production of nitric oxide, inducible nitric oxide synthase protein and mRNA, and cyclooxygenase-2 protein and mRNA in cells both in vivo and in vitro via the administration of extracts and compounds derived from the seeds ofWarb. (), commonly known as African nutmeg. These extracts and compounds, namely,butter,butter acid extract, sargaquinoic acid, sargachromenol, and sargahydroquinoic acid, are also useful in the treatment and prevention of a battery of adverse health conditions in human, animal, and avian subjects that are advanced by the production of nitric oxide or its metabolites and/or by the activity of cyclooxygenase-2. Methods for the isolation ofbutter acid extracts are also provided.