The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2007
Filed:
Jul. 17, 2002
Christopher J. Apolito, Durham, NC (US);
Randy K. Bledsoe, Durham, NC (US);
Millard H. Lambert, Iii, Durham, NC (US);
David D. Mckee, Durham, NC (US);
Valerie Gail Montana, Durham, NC (US);
Kenneth H. Pearce, Durham, NC (US);
Thomas B. Stanley, Durham, NC (US);
Huaqiang Eric Xu, Grand Rapids, MI (US);
Christopher J Delves, Stevenage, GB;
Christopher J. Apolito, Durham, NC (US);
Randy K. Bledsoe, Durham, NC (US);
Millard H. Lambert, III, Durham, NC (US);
David D. McKee, Durham, NC (US);
Valerie Gail Montana, Durham, NC (US);
Kenneth H. Pearce, Durham, NC (US);
Thomas B. Stanley, Durham, NC (US);
Huaqiang Eric Xu, Grand Rapids, MI (US);
Christopher J Delves, Stevenage, GB;
SmithKline Beecham Corporation, Philadelphia, PA (US);
Abstract
A method of modifying a test nuclear receptor (NR) polypeptide is disclosed. The method provides a test NR polypeptide sequence having a characteristic that is targeted for modification; aligning the test NR polypeptide sequence with at least one reference NR polypeptide sequence for which an X-ray structure is available; building a three-dimensional model for the test NR polypeptide using the three-dimensional coordinates of the X-ray structure(s) of at least one reference polypeptide and its sequence alignment with the test NR polypeptide sequence; examining the three-dimensional model of the test NR polypeptide sequence for characteristic differences with the reference polypeptide; and mutating at least one amino acid residue in the test NR polypeptide sequence at a characteristic difference, whereby the test NR polypeptide is modified.