The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2006
Filed:
Oct. 01, 2003
Philip A. Beachy, Baltimore, MD (US);
Ming-jer Tsai, Houston, TX (US);
Sophia Tsai, Houston, TX (US);
Venkatesh Krishnan, Indianapolis, IN (US);
Chien-huan Chen, St. Louis, MO (US);
Philip A. Beachy, Baltimore, MD (US);
Ming-Jer Tsai, Houston, TX (US);
Sophia Tsai, Houston, TX (US);
Venkatesh Krishnan, Indianapolis, IN (US);
Chien-Huan Chen, St. Louis, MO (US);
The Johns Hopkins University School of Medicine, Baltimore, MD (US);
Baylor College of Medicine, Houston, TX (US);
Abstract
The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.