The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2025
Filed:
Jul. 07, 2024
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;
Splisense Ltd., Jerusalem, IL;
Bat Sheva Kerem, Mevaseret Zion, IL;
Efrat Ozeri-Galai, Jerusalem, IL;
Yifat Oren, Jerusalem, IL;
Ofra Barchad-Avitzur, Jerusalem, IL;
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., Jerusalem, IL;
SpliSense Ltd., Jerusalem, IL;
Abstract
The present invention provides oligonucleotides capable of binding to and modulating the splicing of the pre-mRNA of the CFTR gene, including compositions comprising the oligonucleotides, and uses thereof, such as for suppressing the inclusion of a cryptic exon between exon 22 and 23 as a result of the mutation 3849+10Kb C-to-T, optionally in combination with additional CF therapeutics.