Ofra Barchad-avitzur

Title: Ofra Barchad-Avitzur: Innovator in CFTR Gene Modulation

Introduction

Ofra Barchad-Avitzur is a notable inventor based in Jerusalem, Israel. She has made significant contributions to the field of genetic research, particularly in the modulation of the CFTR gene, which is crucial for understanding cystic fibrosis.

Latest Patents

Ofra holds a patent titled "Restoration of the CFTR function by splicing modulation." This invention provides oligonucleotides capable of binding to and modulating the splicing of the pre-mRNA of the CFTR gene. The patent includes compositions comprising these oligonucleotides and their uses, such as suppressing the inclusion of a cryptic exon between exon 22 and 23 due to the mutation 3849+10Kb C-to-T. This innovation may be used in combination with additional CF therapeutics.

Career Highlights

Throughout her career, Ofra has worked with prominent organizations, including Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. and Splisense Ltd. Her work has been instrumental in advancing research in genetic therapies.

Collaborations

Ofra has collaborated with notable colleagues, including Bat Sheva Kerem and Efrat Ozeri-Galai. These partnerships have contributed to her innovative research and development efforts.

Conclusion

Ofra Barchad-Avitzur's work in CFTR gene modulation exemplifies the impact of innovative research on genetic therapies. Her contributions continue to pave the way for advancements in the treatment of cystic fibrosis.