The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 06, 2023

Filed:

Mar. 17, 2017
Applicant:

Lallemand Hungary Liquidity Management Llc, Budapest, HU;

Inventors:

Michelle Oeser, Croydon, NH (US);

Brooks Henningsen, Winchester, NH (US);

Janet Fisher, Norwich, VT (US);

Charles F. Rice, Hopkinton, NH (US);

Allan Froehlich, Norwich, VT (US);

Aaron Argyros, Etna, NH (US);

Rintze M. Zelle, East Thetford, VT (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/395 (2006.01); C12N 1/22 (2006.01); C12P 7/06 (2006.01); C12N 15/113 (2010.01); C12N 15/52 (2006.01); C12N 15/81 (2006.01);
U.S. Cl.
CPC ...
C07K 14/395 (2013.01); C12N 1/22 (2013.01); C12N 15/113 (2013.01); C12N 15/52 (2013.01); C12N 15/815 (2013.01); C12P 7/06 (2013.01); C12P 7/065 (2013.01); Y02E 50/10 (2013.01);
Abstract

The present disclosure relates to the modulation in the RAS/cAMP/PKA signaling pathway for maintaining the propagation efficiency and increasing fermentation efficiency of yeast cells. The present disclosure provides yeast cells having or engineered to exhibit a modulation in signaling in a RAS/cAMP/PKA pathway, depending on conditions. For example the yeast cells can be selected or genetically modified to express a mutated Ras1 protein, a mutated Ras2 protein, a mutated Ira1 protein and/or a mutated Ira2 protein, optionally in combination with specific promoters. Also provided herewith are methods for propagating the yeast cells as well as using the yeast cells to generate a fermented product (such as ethanol).


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