The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2023
Filed:
Jun. 21, 2018
Fondazione Istituto Italiano Di Tecnologia, Genoa, IT;
Politecnico Di Milano, Milan, IT;
Alfonso Gautieri, Milan, IT;
Emilio Parisini, Milan, IT;
Federica Rigoldi, Milan, IT;
Stefano Donini, Milan, IT;
Alberto Redaelli, Milan, IT;
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, Genoa, IT;
POLITECNICO DI MILANO, Milan, IT;
Abstract
The present invention refers to Amadoriase enzyme protein variants having de-glycating activity and improved thermostability compared to the wild type Amadoriase. The present invention refers also to the use of the thermostabilized Amadoriase as deglycating agent, preferably in the food industry. Moreover, the present invention refers to the use of the thermostabilized Amadoriase as diagnostic and/or therapeutic tools. Preferably, the Amadoriase enzyme protein variants of the invention can be used for determining the level of glycated haemoglobin in a biological sample and therefore for monitoring diabetes.