Location History:
- Secane, PA (US) (2007)
- Columbia, MO (US) (2010)
- Columbia, MD (US) (2014)
Company Filing History:
3 out of 1,246 
2 out of 3,688 
Years Active: 2007-2014
Title: Zonggao Shi: Innovator in Anticancer Research
Introduction
Zonggao Shi is a prominent inventor based in Columbia, MD (US), known for his significant contributions to the field of immunosuppressive agents and anticancer research. He holds a total of three patents that focus on novel drug mechanisms aimed at combating cancer.
Latest Patents
His latest patents include compositions related to potent immunosuppressive agents and anticancer agents. These patents describe simplified analogs of pateamine A, which are devoid of the C3-amino and C5-methyl groups. The suitable analogs provide anticancer and antiproliferative effects both in vivo and in vitro. They operate through a novel mechanism of action that includes the inhibition of eIF4A-dependent translation initiation. These analogs are designed to cause cell cycle arrest or induce apoptosis in transformed cells while exhibiting low toxicity to slow-growing normal cells. Furthermore, they target translation initiation factors, making them valuable as anticancer agents and molecular probes for evaluating eukaryotic translation initiation.
Career Highlights
Zonggao Shi has worked with esteemed institutions such as the Texas A&M University System and Johns Hopkins University. His work has significantly advanced the understanding of drug mechanisms in cancer treatment.
Collaborations
Some of his notable coworkers include Daniel Romo and Jun O Liu, who have contributed to his research endeavors.
Conclusion
Zonggao Shi's innovative work in the field of anticancer research and immunosuppressive agents highlights his role as a key inventor in the scientific community. His patents reflect a commitment to developing effective treatments that minimize toxicity while maximizing therapeutic benefits.