Ziye Dong

Title: Innovations in Cell Isolation: The Contributions of Ziye Dong

Introduction

Ziye Dong is an innovative inventor based in Lubbock, Texas. He has made significant contributions to the field of cell isolation technology. His work focuses on improving the efficiency and effectiveness of isolating cells from biological fluids.

Latest Patents

Ziye Dong holds a patent for "Rapid cell isolation and recovery using hollow glass microspheres coated with biodegradable nanostructured films." This invention utilizes hollow glass microspheres (HGMS) with a controlled nanotopographical surface structure to enhance the isolation and recovery of cells from biological fluids. The method involves applying a layer-by-layer (LbL) assembly of negatively charged SiO2 nanoparticles and positively charged poly-L-arginine molecules. A sheathing can be applied to the surface with an enzymatically degradable LbL film made from biotinylated alginate and poly-L-arginine. Additionally, a cap of anti-EpCAM antibodies and anti-fouling PEG molecules can be applied to the sheathed film covering the microspheres. Compared to smooth-surfaced HGMS, the nanotopographically structured HGMS reveals shorter isolation times, enhanced capture efficiency, and lower detection limits in commonly used cancer cell lines. This HGMS-based cell isolation method does not require specialized lab equipment or an external power source, making it suitable for separating targeted cells from blood or other body fluids in resource-limited environments. Ziye Dong has 1 patent to his name.

Career Highlights

Ziye Dong is affiliated with the Texas Tech University System, where he continues to advance research in cell isolation technologies. His work has the potential to impact various fields, including medical diagnostics and therapeutic applications.

Collaborations

Ziye Dong collaborates with Wei Li, contributing to the development of innovative solutions in cell isolation.

Conclusion

Ziye Dong's contributions to the field of cell isolation technology demonstrate his commitment to advancing scientific research and improving medical applications. His innovative patent highlights the potential for significant advancements in the efficiency of cell recovery processes.