Company Filing History:
Years Active: 2016
Title: Innovations by Inventor Zihao Wang
Introduction
Zihao Wang is an accomplished inventor based in Cary, NC (US). He has made significant contributions to the field of biomedical research, particularly in the analysis of protein sialylation and the early detection of diabetes. With a total of 2 patents, his work has the potential to impact healthcare and diagnostics.
Latest Patents
One of his latest patents is focused on the "Rapid and accurate analysis of protein sialylation." This invention relates to methods and kits for analyzing the sialylation of gluco-proteins. The process involves incubating samples of gluco-protein under three different conditions: with beta-galactosidase, with beta-galactosidase and alpha-sialidase, and without any enzyme. Following enzyme treatment, high performance anion exchange chromatography with pulsed amperometric detection (HPAEC PAD) is utilized to quantitatively determine the total galactose in the sample, including non-sialylated and exogenous galactose. This determination allows for the deduction of the percentage of sialylation of the gluco-protein.
Another significant patent by Wang is related to the "Early detection of diabetes." This invention is based on the discovery that hexosamine, particularly the dynamic O-GlcNAcylation of proteins, contributes to insulin resistance, a hallmark of type II diabetes. The invention provides methods for diagnosing individuals at risk of pre-diabetes or diabetes, characterizing hyperglycemia, and identifying proteins associated with hyperglycemia. Additionally, it includes kits for detecting pre-diabetes or diabetes.
Career Highlights
Throughout his career, Zihao Wang has worked with notable organizations such as Grifols, S.A. and The Johns Hopkins University. His experience in these institutions has allowed him to collaborate with leading experts in the field and contribute to groundbreaking research.
Collaborations
Zihao Wang has collaborated with professionals like Jessica Sloan and Kevin Wee, enhancing the scope and impact of his research endeavors.
Conclusion
Zihao Wang's innovative work in the analysis of protein sialylation and diabetes detection showcases his commitment to advancing biomedical research. His patents reflect a dedication to improving healthcare diagnostics and patient outcomes.