Zhongde Wang

Title: Innovations of Zhongde Wang in Vaccine Development

Introduction

Zhongde Wang is a prominent inventor based in Mount Pleasant, SC (US), known for his significant contributions to the field of vaccine development. With a total of six patents to his name, Wang has focused on creating genetically stable vaccines that can effectively combat various diseases.

Latest Patents

Wang's latest patents include the development of genetically stable recombinant modified vaccinia Ankara (RMVA) vaccines and methods of preparation thereof. This innovative vaccine comprises an immunologically effective amount of recombinant modified vaccinia Ankara (rMVA) virus, which is genetically stable after serial passage. The preparation involves constructing a transfer plasmid vector with a modified H5 (mH5) promoter linked to a DNA sequence encoding a heterologous foreign protein antigen. The process includes generating rMVA virus through transfection, identifying rMVA virus expressing foreign protein antigens, conducting serial passage, expanding the identified rMVA virus strain, and purifying the rMVA viruses to form the vaccine. One embodiment of this invention is directed towards a fusion cytomegalovirus (CMV) protein antigen that elicits an immune response when expressed by a vaccine.

Career Highlights

Zhongde Wang has made remarkable strides in his career, particularly through his work at the City of Hope. His research has been pivotal in advancing vaccine technology, contributing to the development of effective immunizations against various pathogens.

Collaborations

Wang collaborates with notable professionals in his field, including his coworker Don Jeffrey Diamond. These collaborations enhance the research and development of innovative vaccine solutions.

Conclusion

Zhongde Wang's work in vaccine development exemplifies the impact of innovative thinking in addressing public health challenges. His contributions continue to pave the way for advancements in immunization technology.