Company Filing History:
Years Active: 2000
Title: Innovations in Oligonucleotide Synthesis by Zhoada Zhang
Introduction
Zhoada Zhang is an accomplished inventor based in Shrewsbury, MA (US). He has made significant contributions to the field of oligonucleotide synthesis, particularly through his innovative work on sulfur transfer reagents. His research has the potential to enhance the efficiency and cost-effectiveness of oligonucleotide production.
Latest Patents
Zhoada Zhang holds a patent for "Sulfur transfer reagents for oligonucleotide synthesis." This patent focuses on two commercially available compounds, 3-amino-1,2,4-dithiazole-5-thione and xanthane hydride, which have been identified as potential sulfur-transfer reagents. The research demonstrates that these compounds can achieve over 99% sulfur transfer efficiency during the synthesis of dinucleotide and oligonucleotide phosphorothioates. Compared to traditional reagents, these novel sulfur-transfer reagents are stable in various solvents and can be produced in bulk at a low cost.
Career Highlights
Zhoada Zhang has been instrumental in advancing the field of oligonucleotide synthesis through his innovative research. His work has led to the development of efficient sulfur-transfer reagents that can serve as alternatives to existing methods. This advancement is particularly beneficial for large-scale preparations, making the synthesis process more accessible and economical.
Collaborations
Zhoada Zhang has collaborated with notable colleagues, including Yongxin Han and Jimmy X Tang. Their combined expertise has contributed to the successful development and optimization of the sulfur-transfer reagents.
Conclusion
Zhoada Zhang's contributions to the field of oligonucleotide synthesis through his innovative patent on sulfur transfer reagents highlight his role as a leading inventor. His work not only enhances the efficiency of oligonucleotide production but also offers cost-effective alternatives for researchers in the field.