Company Filing History:
1 out of 832,761 Years Active: 2002
Title: Zhigang Shu: Innovator in Mammalian Recombinase Genes
Introduction
Zhigang Shu is a notable inventor based in Bensalem, PA (US). He has made significant contributions to the field of genetic engineering, particularly through his work on mammalian recombinase genes.
Latest Patents
Zhigang Shu holds a patent for his invention titled "Mammalian and human REC2." This invention focuses on mammalian recombinase genes (REC2) and their promoters. The overexpression of REC2 in a cell has been found to facilitate homologous recombination, especially when using a DNA/RNA chimeric oligonucleotide. Additionally, it sensitizes a cell to the apoptotic effects of irradiation. The REC2 promoter, when combined with a strong enhancer, such as an SV40 enhancer, has demonstrated strong activity following cell irradiation. This radiation-inducible promoter can be utilized to sensitize a cell to radiation treatment by operably linking it to a gene that converts a prodrug to a drug, such as the herpes thymidine kinase gene.
Career Highlights
Zhigang Shu's career is marked by his innovative research and development in the field of genetics. His work has implications for improving therapeutic strategies in cancer treatment through enhanced homologous recombination techniques.
Collaborations
Zhigang has collaborated with notable colleagues, including Eric B Kmiec and William K Holloman, who have contributed to his research endeavors.
Conclusion
Zhigang Shu's contributions to the field of genetic engineering, particularly through his patent on mammalian recombinase genes, highlight his role as an innovator in advancing therapeutic techniques. His work continues to influence the landscape of genetic research and treatment methodologies.