Zhigang He

Title: Zhigang He: Innovator in Neural Regeneration and Semaphorin Receptors

Introduction

Zhigang He is a prominent inventor based in San Francisco, CA. He has made significant contributions to the fields of neuroscience and biopharmaceuticals. With a total of 4 patents, his work focuses on advancing our understanding of neural regeneration and semaphorin receptors.

Latest Patents

One of his latest patents involves semaphorin receptors. This invention provides methods and compositions related to two classes of semaphorin receptors, SR1 and SR2. The polypeptides can be produced recombinantly from transformed host cells using the disclosed SR encoding nucleic acids or purified from human cells. Additionally, the invention includes isolated SR hybridization probes and primers that can specifically hybridize with the disclosed SR genes. It also encompasses SR-specific binding agents, such as specific antibodies, and methods for utilizing these compositions in diagnosis, therapy, and the biopharmaceutical industry.

Another significant patent by Zhigang He focuses on promoters of neural regeneration. This invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting a neural cell subject to growth repulsion with an activator of a cyclic nucleotide-dependent protein kinase. The activator may include a direct or indirect activator of the protein kinase, while the repulsion factor typically comprises one or more natural proteins that mediate localized repulsion or inhibition of neural cell growth. The subject compositions include mixtures comprising a neural cell, an activator of a cyclic nucleotide-dependent protein kinase, and a neural cell growth repulsion factor.

Career Highlights

Zhigang He is affiliated with the University of California, where he continues to conduct groundbreaking research. His work has garnered attention in the scientific community, contributing to advancements in understanding neural mechanisms and potential therapeutic applications.

Collaborations

Zhigang He has collaborated with notable scientists, including Marc Tessier-Lavigne and Hang Chen. These collaborations have further enriched his research and expanded the impact of his inventions.

Conclusion

Zhigang He is a distinguished inventor whose work in semaphorin receptors and neural regeneration has the potential to transform therapeutic approaches in neuroscience. His contributions continue to inspire advancements in the field.