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Title: Innovations and Contributions of Inventor Zhidong Chen
Introduction
Zhidong Chen is a notable inventor based in Salt Lake City, UT (US). He has made significant contributions to the field of biotechnology, particularly in the development of oligonucleotides and methods for DNA amplification. With a total of 4 patents, his work has had a profound impact on various scientific applications.
Latest Patents
One of Zhidong Chen's latest patents is focused on inhibitory oligonucleotides targeted to Bcl-2. These oligonucleotides are designed to target specific regions on nucleic acids encoding Bcl-2, with lengths ranging from about 8 to about 50 nucleotides. The invention includes methods for inhibiting Bcl-2 expression in cells, which can be crucial for treating conditions that are influenced by Bcl-2 modulation. Another significant patent involves a method for in vitro amplification of circular DNA. This innovative technique allows for the generation and amplification of closed circular DNA in a cell-free system, utilizing a thermostable DNA ligase in a PCR reaction. This method, known as ligation-during-amplification (LDA), has broad applications in mutagenesis, cloning, and gene therapy.
Career Highlights
Zhidong Chen has worked with esteemed organizations such as the University of Utah Research Foundation and Salus Therapeutics, Inc. His experience in these institutions has allowed him to further his research and development in the field of biotechnology.
Collaborations
Throughout his career, Zhidong Chen has collaborated with notable individuals, including Duane E Ruffner and Michael Pierce. These collaborations have contributed to the advancement of his research and the successful development of his patents.
Conclusion
Zhidong Chen's innovative work in biotechnology, particularly in the areas of oligonucleotides and DNA amplification, showcases his significant contributions to science. His patents reflect a commitment to advancing research and developing new methodologies that can benefit various fields.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.