Company Filing History:
Years Active: 2022-2026
Title: The Innovative Contributions of Zheming Wu
Introduction
Zheming Wu, an inventive mind based in Hangzhou, China, has made significant strides in the field of bioengineering. With a focus on novel nitrilase mutants, his work is paving the way for advancements in the synthesis of chiral intermediates, specifically for pharmaceutical applications.
Latest Patents
Wu holds a patent for a nitrilase mutant, along with the construction method and its application. This invention provides a novel approach to synthesizing a chiral intermediate of pregabalin. By utilizing a peptide fragment displacement method, Wu successfully created nitrilase mutants from turnip nitrilase and Arabidopsis nitrilase. These mutants exhibit enhanced activity in catalyzing and hydrolyzing racemic IBSN, demonstrating substantial improvements over the wild-type nitrilase. The resultant compounds have promising industrial applications, particularly in the efficient catalysis of racemic IBSN to synthesize 3-cyano-5-methylhexanoic acid.
Career Highlights
Zheming Wu is affiliated with Zhejiang University, where he conducts research that bridges academic inquiry with real-world applications. His innovative research centers around bioengineering and enzymology, contributing to the development of environmentally friendly processes for chemical synthesis.
Collaborations
Throughout his career, Wu has worked alongside esteemed colleagues such as Renchao Zheng and Yuguo Zheng. These collaborations have enriched his research endeavors and have driven the advancements in his projects, fostering a spirit of teamwork and shared innovation.
Conclusion
Zheming Wu's contributions to the field of bioengineering and his patented work on nitrilase mutants showcase a promising future for chemical synthesis methodologies. His affiliations and collaborations reflect the importance of teamwork in achieving significant scientific breakthroughs. As advancements in the field continue, Wu’s work will undoubtedly inspire further innovations and applications in the pharmaceutical industry.