This inventor holds 1 USPTO granted patent. Top assignee: Barnes Jewish Hospital. Active years: 1998.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 1998
Title: Innovations of Zhao-Yi Wang in Ubiquitin Conjugating Enzymes
Introduction
Zhao-Yi Wang is a notable inventor based in Millford, CT (US). He has made significant contributions to the field of molecular biology, particularly in the area of ubiquitin conjugating enzymes. His work has implications for both pharmaceutical and non-pharmaceutical applications.
Latest Patents
Zhao-Yi Wang holds a patent for "Ubiquitin conjugating enzymes having transcriptional repressor activity." This patent discloses a human ubiquitin conjugating enzyme, designated hUBC-9, along with its full amino acid sequence and the nucleic acid polymers that encode it. The enzyme not only exhibits functional ubiquitin conjugating activity but also possesses transcriptional repressor activity that is independent of its conjugating function. The conjugating activity of hUBC-9 enhances transcription by degrading transcription suppressor proteins, such as WT1, and potentially hUBC-9 itself. Conversely, the repressor activity of hUBC-9 suppresses gene transcription, likely by disrupting the transcriptional initiation complex through specific interactions with the DNA binding region of the TATA binding protein (TBP). This innovative enzyme can be fused to proteins with a DNA binding domain or used alongside repressors like the Wilm's tumor suppressor gene product, WT1.
Career Highlights
Zhao-Yi Wang is currently associated with Barnes Jewish Hospital, where he continues to advance research in his field. His work has garnered attention for its potential to regulate transcription of target genes effectively.
Collaborations
Zhao-Yi Wang has collaborated with esteemed colleagues, including Thomas E. Shenk and Thomas F. Deuel, contributing to the advancement of knowledge in molecular biology.
Conclusion
Zhao-Yi Wang's innovative work on ubiquitin conjugating enzymes highlights the intersection of molecular biology and therapeutic applications. His contributions are paving the way for future advancements in gene regulation and therapeutic interventions.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile