Yun Ji

Title: Innovations by Inventor Yun Ji

Introduction

Yun Ji is an accomplished inventor based in Germantown, MD, who has made significant contributions to the field of biomedical research. He holds two patents that focus on the modification of T cells for therapeutic applications. His work is pivotal in advancing treatments for various diseases through innovative cellular engineering.

Latest Patents

Yun Ji's latest patents include groundbreaking advancements in T cell modification. The first patent involves T cells modified to overexpress PHF19. This invention provides a mammalian T cell that expresses Phf19 at a higher level than unmodified T cells. The patent also includes a genetically-modified mammalian T cell that comprises a genetic expression vector with sequences derived from viral or bacterial origins, enabling the expression of Phf19 within the T cell. Additionally, it outlines pharmaceutical compositions and methods for treating diseases by inhibiting T cell differentiation through epigenetic reprogramming.

The second patent focuses on T cells modified to overexpress c-Myb. This invention describes an isolated or purified T cell that contains an antigen-specific receptor, such as a T cell receptor (TCR) or a chimeric antigen receptor (CAR). The T cell is modified to express the transcription factor c-Myb at elevated levels compared to unmodified T cells. This patent also encompasses related cell populations, pharmaceutical compositions, and methods for treating diseases and inhibiting T cell differentiation.

Career Highlights

Yun Ji is affiliated with the National Institutes of Health, a component of the US Department of Health & Human Services. His work at this prestigious institution allows him to collaborate with leading experts in the field and contribute to cutting-edge research in immunotherapy and cellular engineering.

Collaborations

Some of Yun Ji's notable coworkers include Luca Gattinoni and Sanjivan Gautam. Their collaborative efforts enhance the research environment and foster innovation in T cell therapies.

Conclusion

Yun Ji's contributions to T cell modification represent a significant advancement in biomedical research. His patents reflect a commitment to improving therapeutic strategies for various diseases. The impact of his work is likely to resonate in the field of immunotherapy for years to come.