Yun-Chi Lu

Title: Innovations of Yun-Chi Lu in Antibody Technology

Introduction

Yun-Chi Lu is a notable inventor based in Kaohsiung, Taiwan. He has made significant contributions to the field of biotechnology, particularly in the development of innovative antibody technologies. His work focuses on creating solutions that enhance the efficacy of protein drugs.

Latest Patents

Yun-Chi Lu holds a patent for an "Antibody locker for the inactivation of protein drug." This invention discloses a hinge antibody capable of being selectively activated in target cells or tissues to treat specific conditions. The hinge antibody comprises a functional antibody, two inhibitory domains, and four cleavable linkers. The functional antibody is designed to treat conditions in its activated state and consists of two light chains and two heavy chains. Each inhibitory domain includes a hinge domain of an immunoglobulin and consists of two peptide arms. The cleavable linkers are peptide substrates that can be cleaved by enzymes specifically or highly expressed in the target cells or tissues, connecting the peptide arms of the inhibitory domains to the N-terminal of the light and heavy chains of the functional antibody. Additionally, methods for preparing and utilizing this hinge antibody are also disclosed.

Career Highlights

Throughout his career, Yun-Chi Lu has worked with esteemed institutions such as Kaohsiung Medical University and DCB-USA LLC. His experience in these organizations has allowed him to further his research and development in antibody technology.

Collaborations

Yun-Chi Lu has collaborated with notable colleagues, including Tian-Lu Cheng and Chih-Hung Chuang. These partnerships have contributed to the advancement of his innovative projects.

Conclusion

Yun-Chi Lu's work in antibody technology exemplifies the potential of innovative solutions in the medical field. His patent and collaborations highlight his commitment to advancing biotechnology for therapeutic applications.