Company Filing History:
1 out of 832,680 Years Active: 2011
Title: Innovations of Yuichi Nakahara in Trehalose Transport
Introduction
Yuichi Nakahara is a notable inventor based in Tsukuba, Ibaraki, Japan. He has made significant contributions to the field of biotechnology, particularly in the area of cell permeability and trehalose transport. His work has implications for various biological applications, including those in both insects and vertebrates.
Latest Patents
Nakahara holds a patent titled "Method of increasing cell permeability to trehalose by recombinantly producing a trehalose transporter." This patent describes a method for introducing trehalose into cells using a trehalose transporter gene. The gene, designated as Tret1, encodes a protein with 12 trans-membrane structures and is induced by desiccation stress. The functional expression of TRET1 in oocytes demonstrated that the transport activity is specific for trehalose and is independent of extracellular pH and electrochemical membrane potential. The transport direction of TRET1 is reversible, depending on the concentration gradient of trehalose. The apparent Km and Vmax values for TRET1 are extraordinarily high, indicating that TRET1 is a facilitated, high-capacity trehalose-specific transporter. Tret1 is widespread in insects and has been shown to confer trehalose permeability upon cells, including those of vertebrates.
Career Highlights
Nakahara's career is marked by his innovative research and development in the field of biotechnology. His work on trehalose transport has opened new avenues for understanding cellular processes and enhancing cell permeability.
Collaborations
He has collaborated with notable colleagues such as Takahiro Kikawada and Takashi Okuda, contributing to the advancement of research in this specialized area.
Conclusion
Yuichi Nakahara's contributions to the field of biotechnology, particularly through his patent on trehalose transport, highlight his role as an influential inventor. His work continues to impact the understanding of cell permeability and transport mechanisms.
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