This inventor holds 1 USPTO granted patent and 1 EPO patent. Top assignee: Development Center for Biotechnology. Active years: 2020.
Company Filing History:
Years Active: 2020
Title: Innovations of Yuan-Hsin Lu in Vaccine Development
Introduction
Yuan-Hsin Lu is a notable inventor based in Xizhi, Taiwan. He has made significant contributions to the field of vaccine development, particularly through his innovative approach to polysaccharide conjugation.
Latest Patents
Yuan-Hsin Lu holds a patent for "Polysaccharide conjugation with detoxified heat labile enterotoxin (LT) used as vaccine." This invention utilizes a detoxified recombinant heat-labile enterotoxin mutant, LTS61K, as a carrier protein to conjugate polysaccharides. The LTS61K variant includes a mutated mature sub-unit A (LTA) with lysine at amino acid position 61 and a wild-type mature sub-unit B (LTB). Various bacterial capsular polysaccharide antigens were chemically conjugated with the LTS61K protein through a reductive amination reaction. The resulting conjugated polysaccharide-LTS61K products were identified as soluble forms through physical, chemical, and biochemical analyses. Immunization studies in rabbits demonstrated that these conjugated vaccines induce higher polysaccharide-specific IgG titers and greater bactericidal activity compared to polysaccharide alone or polysaccharide mixed with LTS61K. The presence of anti-LTS61K serum IgG antibodies has been shown to alleviate travel diarrhea caused by enterotoxigenic E. coli (ETEC).
Career Highlights
Throughout his career, Yuan-Hsin Lu has worked with various organizations, including the Development Center for Biotechnology and DCB-USA LLC. His work has focused on advancing vaccine technologies and improving public health outcomes.
Collaborations
Yuan-Hsin Lu has collaborated with notable colleagues such as Kuo-Chan Hung and Ta-Tung Yuan. These partnerships have contributed to the success of his research and innovations in the field.
Conclusion
Yuan-Hsin Lu's innovative work in vaccine development, particularly through his patented polysaccharide conjugation techniques, showcases his significant impact on the field of immunology. His contributions continue to advance the understanding and effectiveness of vaccines.