Yu J Zhang

Title: Yu J. Zhang: Inventor in Biomedical Research

Introduction

Yu J. Zhang is an inventor associated with Brookline, Massachusetts, and Dana-Farber Cancer Institute Inc. His patent work concerns modified human monocyte chemoattractant protein-1 (MCP-1), a protein involved in attracting monocytes.

Latest Patents

The provided information identifies one patent for Zhang: “Human monocyte chemoattractant protein-1 (MCP-1) derivatives.” The invention describes MCP-1 derivatives modified to inhibit the protein’s monocyte chemoattractant activity. The modifications include substituting aspartate for tyrosine at position 28, phenylalanine for arginine at position 24, or alanine for aspartate at position 3, and deleting amino acids 2 through 8.

The patent also describes pharmaceutical compositions and methods for administering these derivatives to inhibit MCP-1 activity. One proposed application is preventing restenosis, including after coronary artery angioplasty. Zhang’s listed patent portfolio comprises 1 patent.

Career Highlights

Zhang’s documented invention connects protein engineering with potential therapeutic applications. By altering specific amino acids or deleting a segment of MCP-1, the described approach aims to reduce the protein’s ability to attract monocytes.

Collaborations

Barrett J. Rollins is listed as Zhang’s coworker. The provided information associates Zhang with Dana-Farber Cancer Institute Inc.

Conclusion

Yu J. Zhang’s patent describes engineered MCP-1 derivatives intended to inhibit monocyte chemoattractant activity, with potential applications such as reducing restenosis after angioplasty.