Company Filing History:
Years Active: 2007
Title: The Innovative Contributions of Youhe Gao
Introduction
Youhe Gao is a notable inventor based in Brighton, Massachusetts, recognized for his significant contributions to the field of biomedical research. With a total of three patents to his name, Gao's work focuses on innovative methods to regulate cellular activities, particularly in relation to angiogenesis and NF-κB signaling pathways.
Latest Patents
Among his latest patents, one is titled "Method for PR-39 peptide mediated selective inhibition of IκBα degradation." This invention provides a method for regulating IκBα degradation within living cells, which in turn affects NF-κB activity and NF-κB-dependent gene expression. The approach employs the native PR-39 peptide, facilitating selective interaction with IκBα and proteasomes found in viable cells. The result of this interaction leads to reduced IκBα levels, decreased NF-κB activity, and down-regulated NF-κB-dependent gene expression.
Another important patent is "Method for PR-39 peptide regulated stimulation of angiogenesis." This invention details a method for regulating angiogenesis using the PR-39 peptide, which interacts directly with the α7 subunit of proteasomes in viable cells. This effect results in decreased degradation of active peptides such as HIF-1α, thereby stimulating angiogenesis within living tissues and organs in situ.
Career Highlights
Youhe Gao is affiliated with Beth Israel Deaconess Medical Center, Inc., where he continues to advance his research and contributions to the medical field. His work has shown promise not only in understanding fundamental biological processes but also in potential therapeutic applications.
Collaborations
Collaborating with prominent colleagues like Michael Simons, Gao's innovative research has further enriched the scientific community's understanding of cellular mechanisms and their implications for health and disease. These collaborations have been pivotal in enhancing the impact of his inventions.
Conclusion
In summary, Youhe Gao stands out as an accomplished inventor whose work has made significant strides in the biomedical field. His patents demonstrate a commitment to innovation and practical application, highlighting the importance of research in improving human health. As he continues to explore the intricacies of cellular regulation, Gao's contributions will undoubtedly shape future scientific advancements.