Location History:
- Tokyo, JP (2003 - 2008)
- Toyama, JP (2006 - 2012)
Company Filing History:
8 out of 31 
1 out of 2 Years Active: 2003-2012
Title: Innovations of Yoshiyuki Nagai
Introduction
Yoshiyuki Nagai is a prominent inventor based in Toyama, Japan. He has made significant contributions to the field of virology, particularly in the development of vaccines. With a total of 8 patents, his work has the potential to impact public health positively.
Latest Patents
One of his latest patents focuses on AIDS virus vaccines using a Sendai virus vector. This invention provides a vaccine containing a Sendai virus vector that encodes a virus protein of an immunodeficiency virus. By intranasally administering this vaccine to a macaque monkey, Nagai and his team have successfully induced protective immunity against the immunodeficiency virus. The results showed that the expression of an antigen protein mediated by the Sendai virus vector was detected in the intranasal mucous membrane and local lymph nodes, leading to a significant antigen-specific cellular immune response. Importantly, no pathological symptoms were observed following vaccination. After exposure to simian immunodeficiency virus, the amount of virus in plasma significantly decreased compared to that of the control animal, indicating the vaccine's promising potential as an AIDS vaccine.
Another notable patent involves a method for regenerating Sendai virus particles. This method allows for the transfection of the Sendai virus genome into a host that expresses all genes necessary for initial viral replication. This advancement enables genetic manipulation of the Sendai virus and its effective utilization as a vector.
Career Highlights
Nagai has worked with several organizations, including Dna Vec Research Inc. and the National Institute of Infectious Diseases in Japan. His innovative research has positioned him as a key figure in the field of infectious disease research.
Collaborations
Throughout his career, Nagai has collaborated with notable colleagues, including Mamoru Hasegawa and Atsushi Kato. These partnerships have contributed to the advancement of his research and the development of effective vaccines.
Conclusion
Yoshiyuki Nagai's contributions to vaccine development, particularly in the context of AIDS, highlight his innovative spirit and dedication to public health. His work continues to pave the way for future advancements in virology and immunology.