The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2012
Filed:
Feb. 05, 2010
Munehide Kano, Hino, JP;
Tetsuro Matano, Adachi-ku, JP;
Atsushi Kato, Hamura, JP;
Yoshiyuki Nagai, Toyama, JP;
Mamoru Hasegawa, Tsukuba, JP;
Munehide Kano, Hino, JP;
Tetsuro Matano, Adachi-ku, JP;
Atsushi Kato, Hamura, JP;
Yoshiyuki Nagai, Toyama, JP;
Mamoru Hasegawa, Tsukuba, JP;
DNAVEC Research Inc., Ibaraki, JP;
Japan as Represented by the Director General of National Institute of Infectious Disease, Tokyo, JP;
Abstract
The present invention provides a vaccine containing a Sendai virus vector encoding a virus protein of an immunodeficiency virus. By intranasally administering a Sendai virus encoding a virus protein of an immunodeficiency virus to a macaque monkey, the present inventors have succeeded in efficiently inducing protective immunity against an immunodeficiency virus. As a result of intranasal inoculation of vaccine, expression of an antigen protein mediated by Sendai virus vector was detected in intranasal mucous membrane and local lymph nodes and antigen-specific cellular immune response was induced at a significant level. No pathological symptom by vaccination was observed. After vaccination, exposure of simian immunodeficiency virus was performed and the effect was examined. As a result, the amount of virus in plasma significantly decreased, compared with that of the control animal. The present invention provides a promising vaccine as an AIDS vaccine.