Noda, Japan

Yoshio Shirokane


Average Co-Inventor Count = 3.4

ph-index = 1

Forward Citations = 3(Granted Patents)


Company Filing History:


Years Active: 1981-1985

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2 patents (USPTO):Explore Patents

Title: The Innovations of Yoshio Shirokane

Introduction

Yoshio Shirokane is a notable inventor based in Noda, Japan. He has made significant contributions to the field of biochemistry, particularly through his innovative patents. With a total of 2 patents, Shirokane has focused on enzymes that play crucial roles in various chemical processes.

Latest Patents

One of his latest patents is for a monomethylamine-oxidizing enzyme. This enzyme can be obtained by cultivating a strain from the Genus Bacillus, which has the ability to produce it. The enzyme is known for its beneficial properties, including the oxidative deamination of monomethylamine, resulting in formaldehyde, ammonia, and hydrogen peroxide. It exhibits high substrate specificity for monomethylamine, ethylamine, and n-proplyamine, while showing no specificity for benzylamine, dimethylamine, trimethylamine, ethylenediamine, and tryamine. Additionally, the enzyme remains stable across a wide temperature range, allowing for faster reaction rates and shorter evaluation times. Its low Km value enables the use of smaller quantities of the enzyme per sample.

Another significant patent is for a methylguanidine-decomposing enzyme and the process for its production. This enzyme can be obtained by cultivating a bacterium from the Genus Alcaligenes. It has the ability to decompose methylguanidine into methylamine and urea. The enzyme operates optimally at a pH range of 10.9-12.3 and remains stable within a pH range of 5.0-10.6.

Career Highlights

Throughout his career, Yoshio Shirokane has worked with prominent companies such as Kikkoman Corporation and Kikkoman Shoyu Co., Ltd. His work has significantly impacted the field of enzymology and biochemistry.

Collaborations

Shirokane has collaborated with notable individuals in his field, including Motoo Nakajima and Kiyoshi Mizusawa. These collaborations have furthered his research and innovations.

Conclusion

Yoshio Shirokane's contributions to enzyme research and development highlight his role as a significant inventor in the field. His innovative patents demonstrate the potential for practical applications in biochemistry and related industries.

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