Company Filing History:
Years Active: 2014-2017
Title: Innovations of Yonghui Yuan in Capsular Polysaccharide Production
Introduction
Yonghui Yuan is an accomplished inventor based in Tappan, NY (US). He has made significant contributions to the field of biochemistry, particularly in the production of capsular polysaccharides. With a total of 3 patents to his name, his work has the potential to impact various applications in medicine and biotechnology.
Latest Patents
Yonghui Yuan's latest patents describe a shortened process for producing a solution containing substantially purified capsular polysaccharides from a cellular lysate broth. The process involves ultrafiltering and diafiltering a clarified lysate, followed by pH adjustment to less than 4.5, preferably about 3.5. This method precipitates at least 98% of the protein in the solution without significantly affecting polysaccharide yield. Additionally, after ultrafiltration, diafiltration, and acidification to a pH of less than 4.5, filtration using activated carbon precipitates at least 90% of the remaining protein while maintaining polysaccharide yield. The exemplary serotypes that can be purified using this process include 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. In one embodiment, the cells are lysed using deoxycholate sodium (DOC), while in another, a non-animal derived lytic agent such as N-lauryl sarcosine sodium (NLS) is utilized.
Career Highlights
Yonghui Yuan is currently associated with Wyeth, a prominent company in the pharmaceutical industry. His innovative approaches to polysaccharide production have garnered attention and recognition within the scientific community.
Collaborations
Yonghui has collaborated with notable colleagues, including Mark Edward Ruppen and Wei-Qiang Willie Sun. Their combined expertise has contributed to advancements in their field.
Conclusion
Yonghui Yuan's work in the production of capsular polysaccharides showcases his innovative spirit and dedication to scientific advancement. His patents reflect a commitment to improving biotechnological processes, which may lead to significant benefits in various applications.