Yonghui Ge

Title: Innovations and Contributions of Inventor Yonghui Ge

Introduction

Yonghui Ge is a notable inventor based in Suzhou, China. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the development of novel compounds and manufacturing processes.

Latest Patents

Yonghui Ge holds two patents, showcasing his innovative work. His latest patents include the synthesis of a bis-mesylate salt of 4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide and intermediates thereto. This manufacturing process features several efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction. This reaction generates thienopyrimidine and a highly chemoselective Pt/V/C-catalyzed nitro group reduction to access the penultimate intermediate. The final amide coupling was accomplished using a mild and safe protocol, resulting in a compound with excellent yield, purity, and form stability. Additionally, he has developed novel pyrimidine derivatives and pharmaceutical compositions that can be used to treat conditions responsive to the inhibition of various kinases.

Career Highlights

Throughout his career, Yonghui Ge has worked with prominent companies, including Genentech, Inc. His work has significantly impacted the pharmaceutical industry, particularly in the development of protein kinase inhibitors.

Collaborations

Yonghui Ge has collaborated with notable colleagues, including Bei Chen and Tao Jiang. Their combined expertise has contributed to the advancement of innovative solutions in their field.

Conclusion

Yonghui Ge's contributions to pharmaceutical chemistry and his innovative patents highlight his role as a leading inventor. His work continues to influence the development of new therapeutic compounds and manufacturing processes.