Company Filing History:
Years Active: 2010-2012
Title: Innovations of Yong Y Chen
Introduction
Yong Y Chen is a notable inventor based in Lake Villa, IL (US). He has made significant contributions to the field of pharmaceuticals, particularly in the synthesis of complex compounds. With a total of 2 patents, his work has garnered attention for its innovative approaches.
Latest Patents
One of his latest patents is titled "One pot synthesis of tetrazole derivatives of rapamycin." This invention presents a single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on a large scale. The method improves upon currently available synthesis schemes. In this process, dried rapamycin is dissolved in isopropylacetate (IPAc), and the solution is cooled. Following this, 2,6-Lutidine is added, and triflic anhydride is slowly introduced at -30°C. Salts are subsequently removed by filtration. Tetrazole, along with a tert-base diisopropylethylamine (DIEA), is added to the triflate solution. After incubation at room temperature, the product is concentrated and purified using a silica gel column with THF/heptane as the eluant. The fractions containing the product are collected, concentrated, and purified again using an acetone/heptane column. The product is then dissolved in t-BME and precipitated with heptane. The solids are treated with butylated-hydroxy toluene (BHT) and the solution is concentrated. This process is repeated twice with acetone to remove solvents, and at least one stabilizing agent, such as BHT at 0.5%, is added before drying.
Career Highlights
Yong Y Chen is currently employed at Abbott Laboratories Corporation, where he continues to innovate in the field of pharmaceutical synthesis. His work has been instrumental in developing more efficient methods for producing important medical compounds.
Collaborations
Some of his notable coworkers include Madhup K Dhaon and Chi-nung Hsiao, who have collaborated with him on various projects.
Conclusion
Yong Y Chen's contributions to the field of pharmaceutical synthesis through his innovative patents highlight his role as a significant inventor. His work not only advances scientific knowledge but also has practical applications in medicine.