Yong Nian

**Title: The Innovative Contributions of Yong Nian**

Introduction

Yong Nian, an esteemed inventor based in Shanghai, China, has made significant contributions to the field of synthetic chemistry. His innovative work focuses on the development of a method for synthesizing novel chiral ligands and various non-natural amino acids, which has implications for pharmaceutical advancements.

Latest Patents

Yong Nian holds a patent for a **Method for synthesizing novel chiral ligand, metal chelate, a variety of non-natural amino acids, maraviroc and key intermediate thereof**. This invention discloses a process in which (R)-2-methyl proline is utilized as the starting raw material. Through asymmetric resolution facilitated by a nickel chelate, (S)-β-amino acid is produced. Notably, Maraviroc is synthesized using (S)-3-amino-3-phenylpropionic acid as a key intermediate, achieving high yields with an enantiomeric excess (ee) value of 98.2% or more. The method is characterized by the availability of raw materials, mild synthetic conditions, and the production of high-optical purity products.

Career Highlights

Yong Nian is affiliated with the Chinese Academy of Sciences, where he engages in cutting-edge research and development. His role at this prestigious institution has positioned him as a key figure in the innovative landscape of chemical synthesis.

Collaborations

Throughout his career, Yong Nian has collaborated with notable colleagues such as Hong Tao Liu and Jiang Wang. These partnerships have enriched his research endeavors and contributed to the advancement of their collective work in the field.

Conclusion

Yong Nian exemplifies the spirit of innovation in synthetic chemistry through his patent and collaborative efforts at the Chinese Academy of Sciences. His method for synthesizing chiral ligands and amino acids not only demonstrates ingenuity but also holds promise for future pharmaceutical applications, highlighting the importance of inventors in advancing scientific knowledge and technology.