Yihan Zhang

Title: Innovations by Yihan Zhang in Pharmaceutical Development

Introduction

Yihan Zhang is a notable inventor based in Hubei, China, recognized for his contributions to pharmaceutical innovations. He holds two patents that focus on the development of compounds with significant therapeutic potential. His work primarily revolves around lysophosphatidic acid receptor antagonists and triazole compounds, which have promising applications in treating various diseases.

Latest Patents

Yihan Zhang's latest patents include a lysophosphatidic acid receptor antagonist and its preparation method. These compounds exhibit high LPAR1 antagonist activity and selectivity, with low toxicity and good metabolic stability. They show promising prospects for pharmaceutical development and may be utilized in preventing or treating LPAR1-related diseases. The IC50 values of some compounds can be as low as 300 nM or even below 50 nM, while the CC50 value range can exceed 200 μM. Additionally, these compounds demonstrate good metabolic stability in humans, mice, and rats.

Another significant patent by Zhang involves triazole compounds and their preparation method. These compounds also exhibit strong LPAR1 antagonistic activity and selectivity, low toxicity, and good metabolic stability. They can be used for preventing or treating LPAR1-related diseases. The IC50 values for some triazole compounds can be below 300 nM, with some even reaching below 50 nM. The CC values for these compounds can be greater than 200 μM, and they show good metabolic stability in humans, fancy rats, and house mice.

Career Highlights

Yihan Zhang is associated with Wuhan Ll Science and Technology Development Co., Ltd., where he continues to innovate in the field of pharmaceutical research. His work has garnered attention for its potential impact on healthcare and disease management.

Collaborations

Zhang collaborates with notable colleagues, including Jun Lou and Yongkai Chen, who contribute to his research endeavors. Their combined expertise enhances the development of innovative solutions in the pharmaceutical industry.

Conclusion

Yihan Zhang's contributions to pharmaceutical innovations through his patents highlight the potential for new treatments in healthcare. His work on lysophosphatidic acid receptor antagonists and triazole compounds showcases the importance of research in developing effective therapies.