The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Jan. 15, 2020
Applicant:
Wuhan Ll Science and Technology Development Co., Ltd., Hubei, CN;
Inventors:
Jun Lou, Hubei, CN;
Yongkai Chen, Hubei, CN;
Wei Peng, Hubei, CN;
Yihan Zhang, Hubei, CN;
Xiaodan Guo, Hubei, CN;
Li Liu, Hubei, CN;
Junhua Liu, Hubei, CN;
Lina Qian, Hubei, CN;
Chaodong Wang, Hubei, CN;
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
C07D 249/06 (2006.01); C07D 213/65 (2006.01); C07D 263/22 (2006.01); C07D 401/04 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); C07D 413/04 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
C07D 249/06 (2013.01); C07D 213/65 (2013.01); C07D 263/22 (2013.01); C07D 401/04 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01);
Abstract
Certain triazole compounds have good LPAR1 antagonistic activity and selectivity, low toxicity, and good metabolic stability, and can be used for preventing or treating the LPAR1-related disease or disorder. The ICvalue of some triazole compounds can be below 300 nM, even 50 nM. The range of CCof the triazole compounds can be greater than 200 μM. They also show good metabolic stability in human, fancy rats, and house mice.