Location History:
- Gainesville, FL (US) (1999 - 2002)
- Lazal, CA (2005)
Company Filing History:
Years Active: 1999-2005
Title: Innovations in Gene Delivery: The Contributions of Yi Li
Introduction
Yi Li, an accomplished inventor based in Gainesville, FL, has made significant contributions to the field of gene therapy through his innovative work. With a total of five patents to his name, his latest inventions reflect the cutting-edge research being conducted at the intersection of biotechnology and molecular genetics.
Latest Patents
One of Yi Li's most notable patents involves "Materials and methods for delivery and expression of heterologous DNA in vertebrate cells." This invention introduces recombinant entomopox vectors that facilitate the delivery and stable expression of foreign DNA in vertebrate cells. Specifically, the recombinant EPV (from AmEPV) proves advantageous due to its ability to incorporate DNA sequences larger than 10 kb, thereby enabling the delivery of large DNA inserts useful in gene therapy protocols. Furthermore, this patent encompasses novel AmEVP polypeptides and the corresponding polynucleotide sequences that encode these proteins.
Another crucial patent from Yi Li pertains to the "Entomopoxvirus expression system," which offers a groundbreaking approach in biotechnology. This invention discusses novel EPV polynucleotide sequences that are free from their natural viral associations, alongside recombinant polynucleotide vectors, recombinant viruses, and host cells that have been infected with these recombinant viruses. The methods associated with this patent allow for the expression of heterologous proteins in both insect and mammalian cells, further paving the way for advancements in gene therapy applications.
Career Highlights
Yi Li has established a prominent career at the University of Florida Research Foundation, Incorporated, where he is engaged in transformative research that seeks to push the boundaries of genetic engineering. His work not only enhances our understanding of gene delivery mechanisms but also contributes to the broader application of these technologies in medical therapies.
Collaborations
Throughout his career, Yi Li has collaborated with distinguished colleagues such as Richard W Moyer and Richard L Hall. These collaborations underscore the importance of teamwork in driving innovation and fostering advancements in the rapidly evolving field of biotechnology.
Conclusion
In summary, Yi Li’s contributions to gene therapy through his innovative patents highlight the potential of using recombinant entomopox virus vectors to improve DNA delivery systems. His ongoing work at the University of Florida Research Foundation exemplifies the impact that dedicated researchers have in the realm of medical biotechnology, ultimately enhancing therapeutic options for various diseases.