Company Filing History:
Years Active: 2001
Title: Yi-Fan Zhang: Innovator in Hepatitis E Research
Introduction
Yi-Fan Zhang is a prominent inventor based in Mountain View, CA (US). He has made significant contributions to the field of virology, particularly in the study of hepatitis E virus (HEV). With a total of 2 patents, his work has implications for both diagnostics and vaccine development.
Latest Patents
Yi-Fan Zhang's latest patents focus on hepatitis E virus antigens and their uses. The first patent describes antigens derived from the enterically transmitted non-A/non-B viral hepatitis agent, known as hepatitis E virus (HEV). These antigens, particularly a soluble 62 kDa species of the capsid protein encoded by ORF2, are immunoreactive with sera from individuals infected with HEV. The 62K antigen can be produced using a baculovirus expression vector and forms virus-like particles (VLPs). These antigens are valuable as diagnostic reagents in methods and kits for determining HEV infection in individuals. Additionally, they are useful in vaccine compositions aimed at preventing HEV infection.
The second patent also addresses hepatitis E virus antigens, focusing on soluble species of the capsid protein encoded by the carboxy terminal region of HEV ORF2. Similar to the first patent, these antigens are immunoreactive with sera from infected individuals and can be produced by a baculovirus expression vector to form VLPs. They serve as diagnostic reagents and are effective in vaccine compositions for preventing HEV infection.
Career Highlights
Yi-Fan Zhang is associated with Genelabs Technologies, Inc., where he continues to advance research in hepatitis E. His innovative work has positioned him as a key figure in the development of diagnostic tools and vaccines for viral infections.
Collaborations
Some of his notable coworkers include Thomas R Fuerst and C Patrick McAtee, who have collaborated with him on various research projects.
Conclusion
Yi-Fan Zhang's contributions to hepatitis E research through his patents and collaborations highlight his role as an innovator in the field. His work not only enhances our understanding of HEV but also paves the way for improved diagnostic and preventive measures against this viral infection.