This inventor holds 3 USPTO granted patents, plus 1 CIPO patent and 2 EPO patents. Top assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services. Active years: 2016-2017.
Company Filing History:
Years Active: 2016-2017
Title: Yen T Phung: Innovator in Monoclonal Antibodies
Introduction
Yen T Phung is a prominent inventor based in Annandale, VA (US). She has made significant contributions to the field of biotechnology, particularly in the development of monoclonal antibodies. With a total of 3 patents, her work has the potential to impact cancer treatment and diagnostics.
Latest Patents
One of her latest patents focuses on "Mesothelin domain-specific monoclonal antibodies and use thereof." This patent describes the use of rabbit hybridoma technology, along with a panel of truncated mesothelin domain fragments, to identify anti-mesothelin monoclonal antibodies (mAbs) that bind specific regions of mesothelin. The identified mAbs, including YP187, YP223, YP218, and YP3, bind either Region II (391-486) or Region III (487-581) with subnanomolar affinity. Importantly, these antibodies do not compete for binding with the mesothelin-specific immunotoxin SS1P or the mesothelin-specific antibody MORAb-009. Additionally, a high-affinity rabbit mAb, YP158, has been disclosed, which binds Region I of mesothelin, demonstrating high affinity and specificity for native mesothelin protein in cancer cells and tissues.
Career Highlights
Yen T Phung works for the United States of America, as represented by the Secretary, Department of Health and Human Services. Her innovative research has positioned her as a key figure in the development of therapeutic antibodies.
Collaborations
Yen has collaborated with notable coworkers, including Mitchell Ho and Yifan Zhang, contributing to the advancement of her research and the field of monoclonal antibodies.
Conclusion
Yen T Phung's work in developing mesothelin domain-specific monoclonal antibodies showcases her innovative spirit and dedication to improving cancer treatment. Her contributions are paving the way for future advancements in biotechnology.