Company Filing History:
1 out of 832,680 Years Active: 2011
Title: Innovations of Yasushi Kanamori
Introduction
Yasushi Kanamori is a notable inventor based in Tsukuba, Ibaraki, Japan. He has made significant contributions to the field of biotechnology, particularly in the area of cell permeability and trehalose transport.
Latest Patents
Kanamori holds a patent for a method of increasing cell permeability to trehalose by recombinantly producing a trehalose transporter. This patent describes the trehalose transporter gene and a method for introducing trehalose into cells using this gene. The candidate for the trehalose transporter genes was identified in EST, leading to the discovery of a cDNA designated as Tret1. Tret1 encodes a 504 amino acid protein with 12 trans-membrane structures. The expression of Tret1 is induced by desiccation stress and is predominantly found in the fat body. Functional expression of TRET1 in oocytes demonstrated that the transport activity is specific for trehalose and is independent of extracellular pH and electrochemical membrane potential. The direction of transport of TRET1 is reversible, depending on the concentration gradient of trehalose. The apparent Km and Vmax of TRET1 for trehalose are extraordinarily high values. These findings indicate that TRET1 is a facilitated, high-capacity trehalose-specific transporter, which is widespread in insects. Furthermore, TRET1 confers trehalose permeability upon cells, including those of vertebrates as well as insects. Kanamori has 1 patent to his name.
Career Highlights
Throughout his career, Yasushi Kanamori has focused on the intersection of biotechnology and cellular biology. His work has contributed to a deeper understanding of how trehalose can be utilized in various biological systems.
Collaborations
Kanamori has collaborated with notable colleagues such as Takahiro Kikawada and Takashi Okuda, enhancing the impact of his research through teamwork and shared expertise.
Conclusion
Yasushi Kanamori's innovative work in the field of trehalose transport has opened new avenues for research and application in biotechnology. His contributions are significant and continue to influence the scientific community.
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